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Levoleucovorin Calcium (CL307782) 是一种亚叶酸的钙盐,在癌症化疗中用作辅助剂。
Levoleucovorin Calcium (CL307782) 是一种亚叶酸的钙盐,在癌症化疗中用作辅助剂。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | ¥ 233 | 现货 | |
25 mg | ¥ 372 | 现货 | |
50 mg | ¥ 538 | 现货 | |
100 mg | ¥ 788 | 现货 | |
500 mg | ¥ 1,730 | 现货 | |
1 g | ¥ 2,570 | 现货 | |
2 g | ¥ 3,390 | 现货 |
产品描述 | Levoleucovorin Calcium (CL307782), a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant. |
激酶实验 | Chk1 Assay: For the Chk1 assay, the kinase domain is expressed in Sf9 insect cells, and a biotinylated cdc25c peptide containing the consensus Chk1/Chk2 phosphorylation site (*)(biotin-[AHX]SGSGS*GLYRSPSMP-ENLNRPR[CONH2]) is used as the substrate. A dilution series of CHIR-124 is mixed with a kinase reaction buffer containing a final concentration of 30 mM Tris-HCl (pH 7.5), 10 mM MgCl2, 2 mM DTT, 4 mM EDTA, 25 mMβ-glycerophosphate, 5 mM MnCl2, 0.01% bovine serum albumin, 1.35 nM CHK1 kinase domain, 0.5 μM peptide substrate, and 1 AM unlabeled ATP, plus 5 nM 33Pγ-labeled ATP (specific activity = 2,000 Ci/mmol). Reactions and detection of the phosphate transfer are carried out by a radioactive method. Reactions are incubated at room temperature for 1 to 4 hours and the phosphorylated peptide captured on streptavidin-coated microtiter plates containing stop reaction buffer (25 mM EDTA [ethylenediaminetetraacetic acid], 50 mMHEPES, pH 7.5). Phosphorylated peptide is measured with the DELFIA TRF system using a Europium-labeled anti-phosphotyrosine antibody PT66. The concentration of CHIR-124 for IC50 is calculated using nonlinear regression with XL-Fit data analysis software. |
别名 | 左亚叶酸钙, CL307782, Calcium Levofolinate |
分子量 | 511.5 |
分子式 | C20H21N7O7·Ca |
CAS No. | 80433-71-2 |
Smiles | [Ca++].Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC([O-])=O)C([O-])=O)N(C=O)c2c(=O)[nH]1 |
密度 | no data available |
存储 | keep away from direct sunlight,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | DMSO: Insoluble, The compound is unstable in solution, please use soon. H2O: 10 mM | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
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